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In contrast, MOTS-c concentrations remained relatively stable at HOMA-IR values below 6.6 mg/dLU/mL (95 % CI: 0.512.7

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Moreover, Ex-4 induces autophagy and attenuates ovarian cancer cell viability by upregulating the expression of autophagic markers beclin-1 and microtubule-associated proteins light chain 3I/II (LC3I/II), while simultaneously downregulating the expression of p62 (a linker protein for LC3II) [68]