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As can be seen from the comparison between the example 1 and the comparative example 4, the mixed system of acetonitrile and water is adopted in the example 1 to dissolve the raw materials of N, N-diisopropylethylamine and Arg34GLP-1 (9-37), and meanwhile, the pH is adjusted to 4-6 by acid in the post-treatment, namely, the isoelectric point precipitation is adopted, the purity of the obtained compound 2 is as high as 90% or more, the purity is improved by at least 10% compared with the purity of the compound 4, the complex procedures of removing the organic solvent by rotary evaporation, performing freeze-drying and the like in the prior art are omitted, and the cost can be greatly reduced

When visceral fat decreases but subcutaneous fat stays the same, you might not see scale movement while your waist shrinks, your face looks leaner, and your clothes fit differently

Bradshaw MJ, Holick MF, Stankiewicz JM (2020) Vitamin D and multiple sclerosis

90 ManevichY.FeinsteinS