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First, dysesthesia the tingling or altered skin sensation that has been retatrutide's signature non-GI side effect since Phase 2 was lower than expected: 12.5% on 12 mg versus 0.9% on placebo

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Cercato, The efficacy and safety of GLP-1 receptor agonists in youth with type 2 diabetes: a meta-analysis

In light of the partly opposing effects of GIP on insulin secretion and on fat deposition, we have doubts whether either agonists or antagonists at the GIP receptor will play a therapeutic role [11]