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(2025) 86:e70107
Neither showed any effect on the primary endpoint, the Clinical Dementia Rating-Sum of Boxes at 104 weeks, nor on secondary cognitive and functional scales, and a pooled analysis found no delay in progression from mild cognitive impairment to dementia (hazard ratio 0.96) [1]
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p38 and JNK are associated with pro-inflammatory response and their activation leads to the transcription of proinflammatory cytokine genes like IL-1 , TNF- , and IL-6 , matrix metalloproteinase-9 ( MMP-9 ), and adhesion molecules, VCAM-1 and ICAM-1 , which promote endothelial dysfunction, atherosclerosis and thrombosis [122128]
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