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SNc, substantia nigra pars compacta

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This suggests a prolonged therapeutic window wherein a treatment to elicit neurite outgrowth could potentially reconnect silenced cochlear ganglion cells with hair cells, restore synaptic functions, and improve peripheral sensory input to the CAS

Substantial evidence has shown that renal fibrosis is linked to hyperactive pro-fibrotic molecular players, such as the renin-angiotensin system (RAS), reactive oxygen species (ROS), Toll-like receptor 4 (TLR4), and aryl hydrocarbon receptor (AHR) [22-25]