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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

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(Biochem Pharmacol 2018) documented a reduction of -35% in white adipose tissue, -40% in adipocyte volume, -5.1% in body weight and -30% in plasma cholesterol in just 11 days in obese mice (DIO), without any change in food intake