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The strongly diabetogenic effect of GCs is caused by increased insulin resistance, driven primarily by increased hepatic gluconeogenesis, lipolysis, and elevated circulating free fatty acids (35)

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Source: Hwang, et al JAMA Health Forum March 14, 2025 Researchers from the University of Chicago modeled the clinical and financial impact of anti-obesity medications: Zepbound (tirzepatide), Wegovy (semaglutide), and two oral generic drug combinations, phentermine-topiramate and naltrexone-bupropion