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Pungent vanilloids such as capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a major pungent of hot chili pepper ( Capsicum annuum ) [206, 223], and (10)-shogaol from ginger ( Zingiber officinale ) also activate phase II detoxification enzyme expression in a Nrf2-dependent manner [207]
A small proportion of people experience a temporary rough-texture phase sometimes called the copper peptide uglies, thought to be driven by MMP activity briefly outpacing new collagen synthesis when starting at too high a frequency
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