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22 In addition, AARS1 senses intracellular lactate and serves as a bona fide lactyltransferase that directly uses lactate and ATP to catalyze the lactylation of Yes-associated protein (YAP) at K90 and the transcriptional enhanced associate domain (TEAD) at K108

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Glucose-6-Phosphate Dehydrogenase Deficiency The importance of this enzyme for red cell integrity was first recognized following the observation that some African-American soldiers taking the antimalarial drug primaquine would develop acute hemolytic anemia with hemoglobinuria