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Biol Psychiatry 46 : 14181428

This results in higher levels of free, biologically active androgens, which can: Increase sebum production by sebaceous glands Promote follicular hyperkeratinisation (abnormal skin cell turnover) Contribute to the inflammatory processes underlying acne lesions When GLP-1 medications facilitate significant weight loss and improve insulin sensitivity, these hormonal disturbances may partially normalise

3 Hepatokines In this section, we will consider some of the hepatokines already studied in humans that are related to obesity, insulin resistance, and/or diabetes, and NAFLD

(85) were the first to document the impact of OSAHS on Survivin levels, revealing a significant reduction in plasma Survivin among OSAHS patients, which correlated with nocturnal hypoxia and elevated C-reactive protein levels