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Phase 2 trial data for the CagriSema combination (cagrilintide 2.4mg + semaglutide 2.4mg) demonstrated approximately 15.6% mean weight reduction at 32 weeks substantially exceeding semaglutide alone and positioning amylin/GLP-1 dual agonism as a competitive research frontier alongside GIP/GLP-1 and triple agonist approaches

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also found that mucus hypersecretion and muc5AC mRNA were significantly decreased when enzyme-degradation resistant VIP was delivered to the airways of mice with experimentally induced asthma [117]