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Nauck M A, et al

MK-677's ghrelin agonism increases appetite so dramatically that maintaining a caloric deficit becomes the limiting factor in body composition studies

That central action is the article's explanation for why mood effects are not simply a byproduct of losing weight

Transcriptional activation of G6PD in response to oxidative stress is carried out by the transcription factor, NRF2 (nuclear factor erythroid 2related factor 2)