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However, the precise control of ferroptosis, including its induction, inhibition, and fine-tuning, remains an area of ongoing scientific discourse (128)

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(289) conducted a meta-analysis of 23 RCTs comprising 931 hemodialysis patients, demonstrating that probiotic/prebiotic/synbiotic interventions significantly reduced plasma p-cresyl sulfate (SMD = 0.38, 95% CI: 0.61 to 0.15), endotoxin (SMD = 0.58), CRP (SMD = 0.61), and IL-6 (SMD = 0.92) [Evidence quality: Moderate - significant heterogeneity in intervention protocols]

When insulin sensitivity is low, cells do not respond well to insulin, causing high blood sugar