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Mendelian randomisation, a crucial analytical method for evaluating the causality of the association between risk factors and pertinent clinical outcomes, proves invaluable in instances where conducting randomised clinical trials is unfeasible due to ethical concerns and associated expenses [168,169,170]

This finding may reflect confounding by inhaled corticosteroids since in secondary analyses, the number of exacerbations was significantly lower with N -acetylcysteine treatment in subjects not taking inhaled corticosteroids (risk ratio 0.79 vs

However, limitations include in vivo instability, reliance on biocompatible and robust carriers and restricted application procedures (local and direct)