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In one study of children ages 10 months to 4 years, it was found that APAP lowered the fevers of some children with febrile seizure and a temperature above 38.5 o C more effectively than it lowered the fevers of other children ( APAP PHARMACOKINETICS IN CHILDREN As has been observed with many other drugs, the variability in APAP PK varies with age from birth to adulthood

2.4 Reproducibility and approaches needed where data is not well reproduced With test method validation in mind, chemicals need to be selected on the basis of reproducible data, not a single literature report

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Mice C57BL/6J Gpx4 flox/flox mice 27 were crossed with C57BL/6J Villin-Cre + mice 28 to obtain Gpx4 flox/wt ;Villin-Cre +/ ( Gpx4 +/IEC ) mice or Gpx4 flox/flox ;Villin-Cre +/ ( Gpx4 /IEC ) mice