In addition to the abovementioned limitation, the lack of clinical data beyond preclinical trials limits their potential application in clinical settings
The scoring standard for IHC staining adopted the immunoreactive score (IRS) system [15, 16], with the specific rules as follows: the staining intensity of GGCT protein was classified into four grades, where a score of 0 indicated no staining signal, 1 indicated weak positivity, 2 indicated moderate positivity, and 3 indicated strong positivity
However, these regimens have been plagued with long term drug toxicity leading to retarded neutrite growth, mitochondrial dysfunction, and oxidative stress 18
Foods high in vitamins D and A, especially oily fish, carrots, and sweet potatoes, have been associated with a lower risk of fibroid growth