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Certain groups should always consult with a professional before adding it to their routine: Pregnant or Breastfeeding Women: There is limited research on the effects of shilajit during pregnancy, so it is generally best to avoid it during this time

Signs suggesting cycle extension include continued gradual improvement at cycle end, incomplete resolution of primary concerns, and recent flare or setback

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Filgotinib exhibits 30-fold greater selectivity for JAK1 over JAK2 [397], In phase II studies for RA (NCT01888874, NCT01888874), higher daily doses effectively controlled disease activity, demonstrating superiority over placebo both as monotherapy and in combination therapy