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One is it's a marker of inflammation

Therapeutic potential of natural products against atherosclerosis: targeting on gut microbiota

The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail

However, two critical physiochemical properties hindered drug development: 1) a lack of metabolic stability resulting in short circulating half-lives (eg