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Crucially, the specific papers tying Dihexa to that axis were retracted in 2025 for falsified/fabricated figures, so the mechanism must be treated as unproven pending independent replication [4]

In the trial, published in the Lancet, 930 adults with type 2 diabetes were randomly assigned to receive 4mg, 9mg or 12mg of retatrutide, or placebo

Dulaglutide (Trulicity), administered weekly, has a half-life of approximately 5 days, meaning it takes roughly 3-4 weeks (about 5 half-lives) for 97% elimination