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The compound then received GRAS (Generally Recognized as Safe) designation from the FDA for use as a food ingredient, which is a separate regulatory category from drug approval

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(2) Absorption of cyanocobalamin, coenzyme B12, methylcobalamin, and hydroxocobalamin at different dose levels (3) Intestinal absorption and concurrent chemical changes of methylcobalamin (4) NIH Office of Dietary Supplements: Vitamin B12 (5) B Vitamins: Chemistry, Metabolism, and Health Effects Disclaimer The statements in this article have not been evaluated by the Food and Drug Administration