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In SURPASS trials, patients on metformin plus tirzepatide achieved HbA1c reductions of 2.0-2.5%, with many reaching HbA1c targets below 5.7% (normal range)

Fatigue and dizziness : Some patients report mild fatigue, dizziness, or lightheadedness alongside thirst, particularly early in treatment

In fact, GLP-1 RAs of all stripes have some common side effects worth mentioning, as well as some increased risk factors for other diseases

Why Combining GLP-1 Medications Is Usually Not Recommended Both medications belong to a group of therapies that influence incretin hormones, which help regulate appetite, digestion, and blood sugar levels