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I mean, [00:05:00] really it's, it's imaging that can show you, you know, there are scans like the FTG pet, which basically shows how well the brain is utilizing glucose, which again is, you know, under fed conditions its primary energy substrate
It only mimics GLP-1 while tirzepatide mimics GLP-1 and GIP
Rotation is built into the protocol for a reason
Other groups who should exercise caution or may not be suitable for these medications include: Patients with severe renal impairment particularly those at risk of dehydration from gastrointestinal side effects Individuals with diabetic retinopathy rapid glucose lowering may temporarily worsen retinopathy in people with diabetes Those taking certain medications particularly insulin or sulfonylureas, which increase hypoglycaemia risk Patients with eating disorders the appetite-suppressing effects may exacerbate disordered eating patterns Elderly patients may be more susceptible to dehydration and adverse effects In the UK, NICE guidance (TA875 for semaglutide and TA664 for liraglutide) specifies that these treatments should only be available through specialist weight management services
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