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10.1038/nrgastro.2017.109 107 YuanQ.TangS.ChenS.YangZ

Consider an animal study scenario: a researcher dosing each animal at 250 mcg per kilogram of body weight, using a 1,000 mcg/mL solution

The study, published in the journal Molecular and Cellular Neuroscience , examined 30 preclinical studies investigating the effects of four GLP-1 receptor agonists liraglutide

These findings suggest that a mechanism similar to that observed in mice [10] is at work in humans and that combining metformin with DPP-4 inhibitors appears to be a rational way of enhancing GLP-1 signalling in pancreatic beta cells