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What to avoid : Alcohol consumption during active weight loss phases significantly depletes glutathione

Monitoring parameters typically assessed in trials include: Body weight and BMI measured at each visit to track progress Blood glucose and HbA1c particularly important for participants with type 2 diabetes or non-diabetic hyperglycaemia (sometimes called prediabetes) Lipid profile including total cholesterol, LDL, HDL, and triglycerides Liver function tests given the metabolic effects of glucagon receptor activation Renal function especially relevant if gastrointestinal side effects lead to reduced fluid intake Blood pressure and heart rate cardiovascular parameters are routinely assessed Calcitonin levels some trial protocols include calcitonin measurement given the theoretical thyroid C-cell risk associated with GLP-1 receptor agonists, based on rodent data

10.1111/j.1464-5491.2009.02790.x 94 OkaJ

Our cells have adapted to this potential toxicity by storing cysteine in the form of glutathione (GSH) [8] , which is far more stable to oxidation