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People who are exposed to increased oxidative stress due to malnutrition or environmental toxins can develop a deficiency. In addition, there is a genetic metabolic disorder called glutathione S-transferase deficiency, which causes the body's natural detoxification system to not function properly. A lack of glutathione can manifest itself, for example, in a drop in performance and chronic fatigue, even fatigue syndrome. Since the level of glutathione in the body decreases with age, the substance is also said to have a rejuvenating effect as a natural anti-aging agent. What happens if you overdose on glutathione

PMC 2199391

We dont have to do it gracefully