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You may experience transient nausea, constipation, or mild fatigue as your caloric intake drops

Administration Injectable GLP-1 medications: Self-administered subcutaneous injection Small needle, minimal discomfort for most Common injection sites: abdomen, thigh, upper arm Rotate sites to prevent tissue irritation Most are once-weekly (semaglutide, tirzepatide, dulaglutide) Oral semaglutide (Rybelsus): Must be taken on empty stomach No more than 4 oz water Wait 30 minutes before eating or taking other medications Daily dosing Long-Term Considerations Understanding the long-term picture helps with treatment planning

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[PubMed: 18661239] (28 year old man developed jaundice 3 months after starting Hydroxycut [containing green tea extract] for weight loss [bilirubin 18.1 mg/dL, ALT 2272 U/L, Alk P 152 U/L, ANA 1:40], with rapid improvement on stopping)