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Recently, studies have identified loss of trimethylation at lysine 27 of histone H3 (H3K27me3) in a subset of malignant peripheral nerve sheath tumors reflecting inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED

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This is supported by a large amount of clinical study data showing that obese people lost up to 15% of their body weight