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An excision through a small incision along the areola is performed to remove dense glandular tissue

Ren Y, Kitahara CM, Berrington de Gonzalez A, Clero E, Brindel P, Maillard S, et al

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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder