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The combination of psyllium and magnesium citrate addresses constipation from two different mechanisms: psyllium adds bulk and holds water in the stool, while magnesium draws additional water into the intestine through osmosis

With their mechanism of action, it may be quite different. Petersen said that raises a challenge for future trials: A different mechanism may require a different way of measuring how well it works, something regulators may be reluctant to accept

Microdosing starts at 0.125 mg (sometimes even lower) and increases in smaller increments

The caveat there is, you have to proceed carefully so that you don't decrease the dose to the point the person has a psychotic relapse