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Cardiovascular symptoms : Slow heart rate, low blood pressure, or chest discomfort with cold exposure require prompt evaluation

During treatment, your provider may review your response, tolerability, and whether your plan should continue or be adjusted

In the procedure, bovine insulin was used as an internal standard and added to blood samples, followed by protein precipitation using a mixture of acetonitrile and methanol (70:30,v: v)

Thus, identifying which substances are contained in EVs that transmit drug resistance and developing appropriate therapeutic measures are among the most effective ways to overcome drug resistance