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However, these resulting effects of NRF2 induction via CDDO treatment were to a dramatically lower degree compared to the effects of NRF2 induction upon GSH depletion in Gclc L-KO mice (Figs

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2010 May;151(5):2008-18

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Aggressive media campaigns about its exaggerated effects as a skin lightening agent and over-the-counter availability of this drug have resulted in consumption of improper doses and schedules

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