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The potential synergy arises from the fact that tirzepatide and niacinamide target overlapping metabolic dysfunctions through different mechanisms

doi: 10.1038/s41586-020-2634-9 228 BuscarinuMCCerasoliBAnnibaliVPolicanoCLionettoLCapiMet al

or collapse (possible anaphylaxis) Severe abdominal pain (possible pancreatitis) Signs of infection at the injection site (redness, swelling, discharge, or fever) Persistent vomiting or inability to tolerate fluids Chest pain, palpitations, or difficulty breathing Severe dizziness or loss of consciousness For non-urgent concerns, contact your GP or call NHS 111 for advice

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