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Serious side effects of Contrave may include increased blood pressure and heart rate, seizures, liver damage, and mood changes like worsening depression or suicidal thoughts

Treatment should be prescribed for licensed indications (type 2 diabetes or, in the case of Wegovy, weight management), with potential liver benefits considered a secondary gain

PMID: 42206237 Diabetes Obes Metab Efsubaglutide Alfa attenuates metabolic dysfunction-associated steatohepatitis in mice with improvements in second harmonic generation-derived fibrosis features

Patients were randomized in a 2:1 ratio to either WEGOVY injection or placebo