Such individuals often continue consuming excessive amounts of food even when fully aware of the negative consequences, such as health problems, decreased mobility, and unwanted physical changes (Booth et al., 2008
Nat Commun 12(1):330 [DOI] [PMC free article] [PubMed] [Google Scholar] 32.Theodorakis N, Kreouzi M, Pappas A, Nikolaou M (2024) Beyond calories: individual metabolic and hormonal adaptations driving variability in weight Management-A State-of-the-Art narrative review
This results in a deficiency of dopamine, leading to involuntary, uncontrollable movements including tremors, muscle stiffness, and difficulty with balance and coordination
Conclusion The study found that a bimodal molecular strategy combining NMDA receptor antagonism and glucagon-like peptide-1 receptor antagonism could successfully correct obesity, hyperglycemia, and dyslipidemia in mouse models of metabolic illness