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2) descending pain modulation pathways

This phenomenon may be attributed to two primary factors: first, the high quality sperm obtained through PureSperm density gradient centrifugation may play a crucial role, which has been demonstrated to significantly reduce apoptotic sperm and cellular debris while maintaining a viable sperm recovery rate exceeding 85% [47], second, the supplementation of Vit A and Lup may effectively enhance sperm motility, plasma membrane integrity, acrosome integrity, and antioxidant capacity while reducing sperm apoptosis levels

2.3 The mechanism of gut microbiota affecting the development of AITD As shown in Figure 1 , extensive research has been conducted on the mechanism by which the gut microbiota affects AITD development

Clinical data showed reductions in oxidative stress markers and inflammation alongside preserved bone density [23]