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This effect has been demonstrated in morphine-addicted rodents [3,4,5,6], in morphine-addicted human beings (reviewed in [5,6,7]), and the mechanism elucidated in rodent [8] and human [9,10] hepatocytes at clinically-relevant concentrations of opioids

Methods: Using the MarketScan Commercial Claims databases from January 1, 2008, to December 31, 2017, we combine claims data from the inpatient admissions and outpatient services records to identify patients with CHBV using ICD-9 and 10 codes

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