Yes, according to the brand's published information
Extended Half-Life and Sustained Receptor Engagement The 13-amino acid N-terminal extension and Arg3 substitution reduce IGFBP binding by 7080%, extending the effective half-life from approximately 10 minutes to 2030 hours in rodent plasma resulting in prolonged IGF-1R activation in cell culture and animal models that is not achievable with native IGF-1 or shorter analogues
Elevate homocysteine levels, impairing normal blood vessel function, promoting oxidative stress, and increasing risk of atherosclerosis, cardiovascular disease, insulin resistance, and Type 2 diabetes
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