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Chem Res Toxicol 17(8):9991006 Gerhardsson L, Aaseth J (2016) Guidance for clinical treatment of metal poisoningsuse and misuse of chelating agents

Abbreviations AP-1: Activator protein-1 CAPE: Caffeic acid phenethyl ester EC: Endothelial cell EGCG: Epigallocatechin gallate FLASH Therapy: Flashed High-dose Rate Radiotherapy FOXO: Forkhead box GPx: Glutathione peroxidase GR: Glutathione reductase IL-8: Interleukin-8 IV: Intravenous NOX: NADPH oxidase NF- B: NF-kappa B Nrf2: Nuclear factor-E2-associated factor 2 PI3K-AKT-mTOR: Phosphoinositide 3-kinase\ Protein Kinase B\ Mammalian Target of Rapamycin ROS: Reactive oxygen species REV: Resveratrol SOD: Superoxide dismutase TNF- : Tumor necrosis factor-alpha DHC: Dihydrocurcumin THC: Tetrahydrocurcumin HHC: Hexahydrocurcumin OHC: Octahydrocurcumin References Bray, F., Jemal, A., Grey, N., Ferlay, J

It is to be noted that the BCKDH reaction is essentially irreversible in mammalian cells such that BCKA synthesis depends on essential amino acids, BCAAs, due to the lack of BCKAs de novo synthetases