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This pathway is active during brain development and plays a role in neural repair after injury

In a cohort study with a total of 29,363 patients, out of whom 3,997 were diagnosed with colorectal adenoma, the association between risk of colorectal adenomas and intake of specific carotenoids was analyzed, showing that lycopene intake was negatively correlated with adenoma risk ( Thus, unlike these studies performed in OPMDs, the studies investing the efficacy of lycopene on managing gastrointestinal precancerous lesions were predominantly limited to animal studies, observational studies, or cohort studies, RCTs evaluating on its efficacy are needed in the future

PMCID: PMC8558286

Pozo et al., 2017)