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[15] The human body's rate of iron absorption appears to respond to a variety of interdependent factors, including total iron stores, the extent to which the bone marrow is producing new red blood cells, the concentration of hemoglobin in the blood, and the oxygen content of the blood

Perform a patch test before use and discontinue if irritation develops

With that said, if you have an MTHFR mutation you would be doing your body a favor by having a lifestyle that caters to specifically for people diagnosed with a mutation in their MTHFR gene

(1997) Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study