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Genes affecting neuronal migration, differentiation, and maturation in ASD Modulation of neuronal activity is controlled by proteins that are involved in the pathophysiology of ASD

Oct 20: Sanofi and Regeneron suffered a rare defeat with Dupixent this weekend as the FDA issued a Complete Response Letter to their supplemental Biologics License Application in chronic spontaneous urticaria, an inflammatory skin condition that leads to debilitating hives

Neuronal mitochondrial dysfunction and central hypometabolism not only impair synaptic plasticity in cognitive-related brain regions but also further promote the release of neuronal DAMPs (e.g., mtDNA), which can activate local microglia in the central nervous system, forming a central energy-inflammation positive feedback loop

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