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Cagrilintide is an investigational drug not currently approved alone by the FDA

Sustained weight loss achieved by either drug could reduce the risk of heart disease, stroke, and other cardiovascular complications

MHPAEAs parity requirements may be violated if a health plan strictly limits GLP-1 coverage to medical conditions (e.g., diabetes) and excludes coverage for similarly evidenced reasons related to MH/SUD treatment or imposes utilization management techniques for these drugs that are more restrictive for MH/SUD uses than for medical conditions

In cardiomyocytes, GLP-1RAs improve mitochondrial fragmentation, while restoring mitochondrial morphology and function in diabetes (153,154)