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32 , 33 Since a single value would not capture the real-world variation, we accounted for uncertainty values of 00.10 for the preference weight of 0.05, 0.050.15 for 0.10, and 0.200.30 for 0.25, with a uniform distribution

This schedule was validated in the SURMOUNT clinical trial program, which demonstrated average weight loss of 20 to 25 percent of body weight over 72 weeks at the highest doses

While this is generally only a concern at extremely high doses, patients with unmanaged hypothyroidism should monitor their thyroid function when beginning supplementation

Observational Evidence for GLP-1RAs Real-world data in ARDs, particularly rheumatoid arthritis and systemic lupus erythematosus, suggest GLP-1RA use is associated with lower rates of major adverse cardiovascular events and all-cause mortality, mirroring findings in broader populations