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The S100A9 protein in exosomes from the follicle fluids of PCOS patients may activate the NFB signaling pathway (116), while human umbilical cord mesenchymal-stem-cell-derived exosomes (hUC-MSC-exos) can inhibit NF-B signaling via stimulation of the phosphorylation and degradation of Ik-B, increasing the expression of anti-inflammatory cytokines IL-10, and are capable of activating M2 macrophage polarization

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