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In activated T cells, metabolic fitness and synthetic function has been directly linked to G6PD activity and ROS homeostasis by Ghergurovich and colleagues, who used a novel metabolite reporter and deuterium tracer assays to monitor cellular G6PD activity in the presence of a specific potent inhibitor of G6PD (55)

Three 10-minute walks spread across a day produce the same cardiovascular benefit as one 30-minute session

This hypercatabolism is evident by our data demonstrating depletion of amino acids and upregulation of the urea cycle as judged by elevated levels of urea cycle metabolites such as citrulline