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For researchers studying anti-inflammatory peptides more broadly, comparing notes with compounds like Selank a peptide noted for its immunomodulatory properties may offer complementary research directions

While ammonium accumulation-mediated acidification has been experimentally validated ( in vitro and in vivo ) to drive immunosuppression in the prostate cancer TME, primarily through impairing T cell and NK cell cytotoxicity and promoting M2 macrophage polarization

bioRxiv , (2022)

Insect venom, particularly Hymenoptera venoms, induces a pronounced Th2 response by coopting evolutionary conserved immunological and neurological mechanisms ( Apis mellifera ) venom allergens ( per se and lead to MC degranulation (Figure 1)