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CVS Caremark / Evernorth 20252026 formulary updates Aetna's weight-loss-only PA threshold is BMI 35 or higher stricter than the FDA label (BMI 30, or 27 with a comorbidity)

In our clinics we are increasingly seeing patients losing hair while on GLP-1 therapy

In some patients, this temporarily raises uric acid and can trigger a gout flare in the first few months

This is because hemoglobin A1C (a measure of blood sugar control) and sex hormone-binding globulin (SHBG) are inversely correlated: as A1C improves with weight loss, SHBG levels may rise, which can bind more testosterone and reduce the amount that circulates freely in the bloodstream