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When to Be Concerned In a research context, further evaluation may be warranted if observations include: Rapidly expanding redness beyond the injection site Severe or escalating pain Persistent swelling lasting multiple days Signs of infection (increasing warmth, spreading redness, discharge) Systemic symptoms such as generalized hives, shortness of breath, dizziness, or facial swelling Severe or systemic reactions should be treated as medically significant and require appropriate clinical evaluation

2022;145(9):e72259

Particular emphasis was placed on studies that linked molecular and cellular mechanisms with behavioral or clinical outcomes, thereby enhancing translational relevance

As for microglia, HIV-1 Tat and gp120 proteins promote cell loss and pro-inflammatory response via NLRP3 or NF-B, which is strongly associated with NeuroHIV [27, 125]