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The American Diabetes Association's 2024 Standards of Care explicitly flag the need for dose adjustments of diuretics when initiating GLP-1 receptor agonists in patients at risk for volume depletion [7]

In simpler terms, the immune system responds to less drug than the metabolic system needs

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Both medications are currently listed on the FDA's drug shortages list , and again, when drugs are in shortage, compounding pharmacies are sometimes permitted to make their own versions by combining ingredients, provided they meet certain federal requirements