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In contrast to rAmy, Cagri primarily engages the CTR in a bypass conformation, equivalent to that observed when bound to AMYRs, with 85% of particles in the final particle stack stabilised in this conformation (Fig

doi:10.1056/NEJMcp0801880

Subsequently, as our main purpose, we investigated whether the association between the neurometabolite levels and clinical measures differed significantly between the groups